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M94A0320.TXT
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1994-10-08
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Document 0320
DOCN M94A0320
TI Effect of splenectomy on HIV-related thrombocytopenia and progression of
HIV infection in patients with severe haemophilia.
DT 9412
AU Brown SA; Majumdar G; Harrington C; Bedford M; Winter M; O'Doherty MJ;
Savidge GF; Haemophia Reference Centre, St Thomas' Hospital, London.
SO Blood Coagul Fibrinolysis. 1994 Jun;5(3):393-7. Unique Identifier :
AIDSLINE MED/94355557
AB Between May 1983 and September 1991 eleven patients with severe
haemophilia underwent splenectomy for HIV-related thrombocytopenia. The
sustained complete remission rate (platelets > 100 x 10(9)/l) was 82%
over a mean follow-up period of 54 months. The group was compared with
22 age-matched non-thrombocytopenic HIV seropositive haemophiliacs who
had not undergone splenectomy. Both groups had equivalent use of factor
concentrate and there was no significant difference between the groups
in terms of anti-retroviral treatment. Analysis of clinical progression
of HIV infection and CD4 positive lymphocyte (CD4+) counts, for the time
since splenectomy, revealed no significant difference in progression of
HIV infection in the splenectomized group compared with the control
group. It is concluded that splenectomy is an effective treatment for
HIV-related thrombocytopenia and has no adverse effect on the
progression of HIV infection.
DE Hemophilia/*COMPLICATIONS Human HIV Infections/BLOOD/*COMPLICATIONS
HIV Seropositivity Leukocyte Count Remission Induction *Splenectomy
Thrombocytopenia/COMPLICATIONS/*SURGERY T4 Lymphocytes JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).